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Research Assistant: Molecular Neuroscience - Motor Neuron Degeneration

Project background: 

The research group of Prof Jochen Prehn at the RCSI Centre for Systems Medicine and the Department of Physiology and Medical Physics aims to identify novel prognostic biomarkers and therapeutic targets for the treatment of motor neuron disorders. The team utilizes preclinical in vitro and in vivo models, genomic and proteomic data sets as well as bioinformatics and data-driven systems modelling approaches to develop novel biomarkers and therapeutics. The research team focuses on small non-coding RNAs and their role in the control of translational and transcriptional processes. The group collaborates with and coordinates a large European research networks (RNA-NEURO) funded by the Joint Program in Neurodegenerative Diseases co-funded by Science Foundation Ireland and other European and Canadian funding bodies. The team is also a designated Centre of Excellence in Neurodegeneration Research (CoEN) and is funded through the CoEN Pathfinder initiative. The research infrastructure at the CSM includes cell culture, animal facilities, genomic and proteomic/RPPA analysis infrastructure, Cellomics and high throughput flow Cytometry, confocal microscopy, and a strong biochemistry and bioinformatics infrastructure.

Objectives of post: 

To support our research team of molecular neurobiologist in the identification of predictive/prognostic signatures and novel therapeutic targets by performing gene expression analysis on cell culture, pre-clinical and clinical samples, as well as cell biological studies.

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