Genomics and Human Disease
Research Translational: from Concept to Commercialisation (Full Year)
(i) learn key principles of disease biology;
(ii) understand new technological developments that increase our understanding of disease processes; and
(iii) develop an appreciation of the importance of innovation, business awareness and leadership skills in the translation of discovery science to clinical implementation.
Research Translational: from Concept to Commercialisation (continued)
You will specialise in one of these three research streams:
I. The Precision Cancer Medicine Stream provides students with a unique opportunity to study cancer biology and perform innovative cancer research within the Centre for Cancer Research and Cell Biology (CCRCB). Prospective students are immersed in this precision medicine milieu from day 1, providing for them the opportunity to understand the key principles in discovery cancer biology and how these research advances are translated for the benefit of cancer patients. The strong connectivity with both the biotech and biopharmaceutical sectors provides a stimulating translational environment, while also opening up potential doors for the students future career.
A recent development within CCRCB is the exciting new CCRCB - National Cancer Institute USA (CCRCB-NCI) Doctoral Training Programme (DTP) in Precision Cancer Medicine. The CCRCB-NCI DTP in Precision Cancer Medicine is a unique partnership between Queens and the world-famous NCI in Washington, USA and offers students the opportunity to undertake their research at an international powerhouse for cancer research. Students enrol in the Precision Cancer Medicine stream of the MRes in Translational Medicine and participate in a competitive process during the latter six months of their MRes to be selected to visit the NCI in Washington. Successful candidates meet potential NCI mentors and chose a laboratory project for their PhD. In Years 2-4, students are enrolled on the CCRCB-NCI Doctoral Training Programme (DTP) in Precision Cancer Medicine and perform innovative research at the NCI from Years 2-4, culminating in the award of a PhD from Queens.
II. The Diabetes and Cardiovascular Disease Stream is a specialised pathway within the MRes in Translational Medicine which builds on our major strategic research strength in this globally significant area. It contains two complementary taught modules which develop the foundation provided by undergraduate medicine or biomedical science to provide students with an advanced insight into current understanding of diabetes and cardiovascular complications. These modules will instill an appreciation of how this knowledge is being applied in the search for novel diagnostic, prognostic and therapeutic approaches for the clinical management of cardiovascular disease in diabetic patients which affects over 400 million people worldwide. Within this MRes programme, we offer a wide range of complementary translational research projects focused on the major cardiovascular complications of diabetes, including retinopathy, cardiomyopathy, peripheral vascular disease, nephropathy and pre-eclampsia. Students who select the Diabetes and Cardiovascular Medicine Stream will be taught and mentored within the Centre for Experimental Medicine which is a brand new, purpose-built institute (~7,400m2) at the heart of the Health Sciences Campus. This building represents a significant investment (~£32m) by the University and boasts state-of-the-art research facilities which are supported by a world-leading research-intensive faculty, ensuring that all of our postgraduate students are exposed to a top-quality training experience.
III. The Inflammation, Infection and Immunity Stream is another specialised pathway within the MRes programme and exposes students to exciting concepts and their application in the field of infection biology, antimicrobial resistance, inflammatory processes and the role of immunity in health and disease. There is a strong emphasis on current developments in this rapidly accelerating field of translational medicine. Students will learn how the immune system maintains health, identifies and prevents response. Lectures will provide an in-depth understanding of the immune system, an overview of research models used, key areas of research in inflammatory and immunemediated pathology, and how to use this basic knowledge to identify and test new therapies. There is a considerable emphasis on clinical trial methodology within this stream and students will be introduced to the concepts of clinical trials and approaches to designing a trial to test novel methods to diagnose/prevent or treat illness. There will be an opportunity to obtain a formal accredited certificate of training in good clinical practice (GCP) via this module.
III. The new Drug Discovery Stream has been introduced to provide students from both a biological and chemistry/pharmacy background with an opportunity to explore this exciting research area. The two specialist modules will give students a greater understanding of both the research and industry aspects of drug discovery. Students will learn alongside Queens researchers who are currently undertaking ground breaking research in the areas of target identification including the development of new chemical compounds and the process for drug development including licensing of new chemical equity. Students within this stream will also benefit from exposure to novel methods of drug delivery being developed at Queens and the close links with industry specialist who will present seminar talks to students during the course.
Youll undertake a project in one of the School's three Centres, depending on the research stream that you have chosen.