Research Translational: from Concept to Commercialisation (Full Year)
This module covers the principles of disease biology and new technological developments that increase our understanding of disease processes. It develops an appreciation of the importance of innovation, business awareness and leadership skills in the translation of discovery science to clinical implementation.
Diagnosis and Treatment (Semester 1)
This module provides a comprehensive overview of the diagnosis and treatment of the common solid and haematological malignancies, including breast, ovarian, genitourinary and gastrointestinal cancers as well as the leukaemias. An overview of the common diagnostic pathways in clinical practice will be provided, and this will including gaining an understanding of imaging modalities and histopathological techniques in routine use.
Cancer Biology (Semester 1)
This module provides a comprehensive overview of the fundamental principles of carcinogenesis highlighting how normal control processes are bypassed during tumour formation. The pathogenic mechanisms to be discussed will range from genomic alterations in key gene families, to epigenetic mechanisms of gene control, alterations in kinase activities or protein turnover, or activation of aberrant phenotypes such as invasion and angiogenesis.
Students will make a selection from the following modules:
Precision Cancer Stream
Cancer Genetics & Genomics
This module will provide students with a comprehensive foundation of concepts in genetics and genomics pertaining to cancer aetiology and molecular pathology with emphasis on both inherited predisposition to cancer mediated by germline genetic variation and consideration of the contribution of the tumour genome to disease pathogenicity.
Translational Cancer Medicine
This module provides a comprehensive overview of current cancer treatments and their limitations. The principles of resistance to standard chemo- and radio-therapies will be addressed and how new targeted therapies are being developed to overcome this resistance. Students will also be introduced to the principles of stratified or precision medicine, using molecular biomarkers to select patients most likely to respond to particular therapies.
In addition, students will learn how high throughput technologies such as transcriptome profiling and next generation sequencing can be utilised to identify new biomarkers and anti-cancer drug targets. The module will also cover how novel pre-clinical discoveries are developed and applied in prospective clinical trials.
Radiation Oncology and Medical Physics (ROMP)
Biology of Radiotherapy
This module is taught through a series of lectures and tutorials and will enable students to develop knowledge and skills in understanding the principles of radiation interactions and the molecular basis of radiation response in cells, tissues and tumours. Through the delivery of a multidisciplinary taught programme, students will cover how radiation affects and disrupts cellular processes and use established theoretical models to explore the concepts behind the use of radiation for cancer treatment.
Building on the biological basis of radiotherapy, this module will develop knowledge and skills in understanding clinical radiotherapy and medical imaging. Through the delivery of a multidisciplinary taught programme, students will cover clinical tumour and normal tissue biology, radiological imaging and the design of radiotherapy treatment plans. This will develop the clinical rationale for radiotherapy in the treatment of cancer and highlight emerging treatment combinations and techniques for biomarker discovery in radiation oncology.Biology and Imaging
You will undertake a project in the Centre for Cancer Research and Cell Biology.
This module comprises the write-up contribution to the overall research element of the programme, with the Research Project (SCM 8067). The Dissertation will represent the student's personal studies in the literature, a description of their experimental execution of their project, data presentation, analysis and interpretation, followed by critical discussion and conclusions.